abstract：CONTEXT:Ferulago angulata (Schlecht.) Boiss. (Apiaceae) (FASB) is used to treat liver diseases and has been used both as food and therapeutics by many cultures for thousands of years because of the natural antioxidant compounds. OBJECTIVE:This study determines antioxidant properties of FASB flowers, the levels of mine...

journal_title：Pharmaceutical biology

authors： Kiziltas H,Ekin S,Bayramoglu M,Akbas E,Oto G,Yildirim S,Ozgokce F

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Tranexamic acid is commonly used for curing abnormal bleeding in a variety of diseases. In a previous study, 12 different tetrahydro-2H-1,3,5-thiadiazine derivatives were synthesized from the amine group of tranexamic acid. Their antifibrinolytic and antimicrobial activities were compared with tranexamic acid. ...

journal_title：Pharmaceutical biology

authors： Avuloğlu-Yılmaz E,Yüzbaşıoğlu D,Özçelik AB,Ersan S,Ünal F

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. OBJECTIVE:This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory ...

journal_title：Pharmaceutical biology

authors： Cavalcanti Filho JR,Silva TF,Nobre WQ,Oliveira de Souza LI,Silva E Silva Figueiredo CS,Figueiredo RC,de Gusmão NB,Silva MV,Nascimento da Silva LC,Correia MT

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Virgin coconut oil (VCO) has been reported to possess antioxidative, anti-inflammatory and anti-stress properties. OBJECTIVE:Capitalizing on these therapeutic effects, this study investigated for the first time the potential of VCO on memory improvement in vivo. MATERIALS AND METHODS:Thirty male Wistar rats (...

journal_title：Pharmaceutical biology

authors： Rahim NS,Lim SM,Mani V,Abdul Majeed AB,Ramasamy K

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Clerodendrum viscosum Vent. (Verbenaceae) is a shrub, widely used amongst the natives of India against various diseases. OBJECTIVE:Crude extract of the plant was tested in vitro on a tapeworm Raillietina tetragona Molin (Davaineidae) to evaluate its potential anthelmintic efficacy and ultrastructural changes i...

journal_title：Pharmaceutical biology

authors： Nandi S,Ukil B,Roy S,Kundu S,Lyndem LM

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:The genus Premna (Lamiaceae), distributed throughout tropical and subtropical Asia, Africa, Australia and the Pacific Islands, is used in folk medicine primarily to treat inflammation, immune-related diseases, stomach disorders, wound healing, and skin diseases. OBJECTIVES:This review exhaustively gathers avai...

journal_title：Pharmaceutical biology

authors： Dianita R,Jantan I

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Cranberry has numerous biological activities, including antioxidation, anticancer, cardioprotection, as well as treatment of urinary tract infection (UTI), attributed to abundant phenolic contents. OBJECTIVE:The current study focused on the effect of cranberry juice (CJ) on blue light exposed human retinal pig...

journal_title：Pharmaceutical biology

authors： Chang CH,Chiu HF,Han YC,Chen IH,Shen YC,Venkatakrishnan K,Wang CK

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:A previous study demonstrated that the chloroform extract of Salvia connivens Epling (Lamiaceae) has anti-inflammatory activity. OBJECTIVE:Identification of the active components in the dicholorometane extract (DESC), and, standardization of the extract based in ursolic acid. MATERIAL AND METHODS:DESC was pre...

journal_title：Pharmaceutical biology

authors： González-Chávez MM,Ramos-Velázquez CS,Serrano-Vega R,Pérez-González C,Sánchez-Mendoza E,Pérez-Gutiérrez S

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Total glucosides of peony (TGP), compounds extracted from the dried roots of Paeonia lactiflora Pall, have been reported to have anti-inflammatory and antioxidative activities. However, the protective effect of TGP on liver injury and the underlying mechanisms remains unknown in diabetic rats. OBJECTIVES:Curre...

journal_title：Pharmaceutical biology

authors： Xia LL,Zhu QJ,Wu YG

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:(-)-α-Bisabolol (BISA) is a sesquiterpene alcohol widely used as scent in cosmetic preparations, perfumes, shampoos, toilet soaps and other toiletries with potential for use in the pharmaceutical area. OBJECTIVE:To evaluate the corneal antinociceptive efficacy of BISA and to analyze the best solubilizing agent...

journal_title：Pharmaceutical biology

authors： Teixeira GF,Costa FN,Campos AR

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Griflola frondosa (Fr) S.F. Gray (Meripilaceae) (GF) is a medical mushroom, and its regulation of the immune system is of interest for the treatment of mood disorders. α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors are the central mediator for the treatment of depression. OBJECTIVE:This...

journal_title：Pharmaceutical biology

authors： Bao H,Ran P,Sun L,Hu W,Li H,Xiao C,Zhu K,Du J

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Agastache mexicana (Kunth) Lint & Epling (Lamiaceae) is a plant used in Mexican traditional medicine for the treatment of hypertension, anxiety and so on. OBJECTIVE:To determine the vasorelaxant effect and functional mode of action of dichloromethane-soluble extract from A. mexicana (DEAm) and isolate the cons...

journal_title：Pharmaceutical biology

authors： Flores-Flores A,Hernández-Abreu O,Rios MY,León-Rivera I,Aguilar-Guadarrama B,Castillo-España P,Perea-Arango I,Estrada-Soto S

更新日期：2016-12-01 00:00:00

abstract：CONTEXT:Brassicaceae plants are associated with protection against cancers due to their glucosinolate contents. OBJECTIVES:We investigate fresh leaves, roots and ripe seeds of Lobularia libyca (Viv.) C.F.W. Meissn. (Brassicaceae) to identify their glucosinolate constituents, antimicrobial and cytotoxic activities Mate...

journal_title：Pharmaceutical biology

authors： Al-Gendy AA,Nematallah KA,Zaghloul SS,Ayoub NA

更新日期：2016-12-01 00:00:00

abstract：CONTEXT:Chrysanthemum morifolium Ramat. (Asteraceae) extract (CME) possesses a vasodilator effect in vitro. However, the use of polyphenol-rich CME in the treatment of hypertension-induced cardiac hypertrophy has not been reported. OBJECTIVE:We investigated the effect of polyphenol-rich CME on hypertension-induced car...

journal_title：Pharmaceutical biology

authors： Gao T,Zhu ZY,Zhou X,Xie ML

更新日期：2016-12-01 00:00:00

abstract：CONTEXT:Augmented renal clearance (ARC) refers to enhanced renal elimination of circulating solute, and has attracted wide attention in recent years. OBJECTIVE:This study evaluates the effects of ARC on serum vancomycin concentration in patients administered vancomycin. MATERIALS AND METHODS:This was a retrospective ...

journal_title：Pharmaceutical biology

authors： Chu Y,Luo Y,Qu L,Zhao C,Jiang M

更新日期：2016-12-01 00:00:00

abstract：CONTEXT:High-mobility group box 1 (HMGB1) protein is a highly abundant protein that can promote the pathogenesis of inflammatory. Some experiments have demonstrated a vital role for HMGB1 to modulate the immune function of regulatory T-cells (Tregs). Astragaloside IV (AST IV), an extract from Astragalus membranaceus Mo...

journal_title：Pharmaceutical biology

authors： Li J,Huang L,Wang S,Yao Y,Zhang Z

更新日期：2016-12-01 00:00:00

abstract：CONTEXT:Vicenin-1, a flavonol glycoside, has potent platelet aggregation inhibition, antioxidant, radioprotectants and anti-inflammatory activities. OBJECTIVE:To establish a rapid, simple, precise and sensitive high-performance liquid chromatography (HPLC) method for determination of vicenin-1 in rat plasma, and to in...

journal_title：Pharmaceutical biology

authors： Kandhare AD,Bodhankar SL,Mohan V,Thakurdesai PA

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Marine cyanobacteria offer a robust resource for natural products drug discovery due to the secondary metabolites they produce. OBJECTIVE:To identify novel cyanobacterial compounds that exhibit CNS psychoactive effects. MATERIALS AND METHODS:Cyanobacteria were collected from Las Perlas Archipelago, Panama and...

journal_title：Pharmaceutical biology

authors： Lax NC,Ahmed KT,Ignatz CM,Spadafora C,Kolber BJ,Tidgewell KJ

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Medical therapies for alcohol-induced liver disease are often difficult to handle and limited in efficacy. OBJECTIVE:In an attempt to find natural therapeutics, here, we investigate the preventive effect of persimmon vinegar (PV) and its fractions against alcohol-induced hepatic injury, in addition to the unde...

journal_title：Pharmaceutical biology

authors： Lee HM,Park MY,Kim J,Shin JH,Park KS,Kwon O

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Arecoline is an effective constituent of Areca catechu L. (Arecaceae) with various pharmacological effects. However, investigations also revealed that long use of arecoline could arouse some oral diseases. OBJECTIVE:The present review gathers the fragmented information available in the literature (before 1 Oct...

journal_title：Pharmaceutical biology

authors： Liu YJ,Peng W,Hu MB,Xu M,Wu CJ

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Seaweeds of the genera Turbinaria and Padina have long been used as food and in traditional medicine for treating several diseases. OBJECTIVE:The current study determines the protective efficacy of the brown seaweeds Turbinaria ornata (Turner) J. Agardh (Sargassaceae) and Padina pavonia (Linnaeus) J.V. Lamouro...

journal_title：Pharmaceutical biology

authors： Abdella EM,Mahmoud AM,El-Derby AM

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Termitomyces clypeatus (Lyophyllaceae) is a filamentous edible mushroom, having ethnomedicinal uses. However, information about the antioxidant, anticancer and antitumour properties of this mushroom remains to be elucidated. OBJECTIVE:The study examines the in vitro antioxidant, anticancer and in vivo antitumo...

journal_title：Pharmaceutical biology

authors： Mondal A,Banerjee D,Majumder R,Maity TK,Khowala S

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Ethnobotanical claims of medicinal plants used in northern Maputaland are limited. Objectives To establish scientific validity for a selection of the plants used in Maputaland to treat skin diseases. MATERIALS AND METHODS:Aqueous and dichloromethane-methanol extracts were prepared from 37 plant species which w...

journal_title：Pharmaceutical biology

authors： Nciki S,Vuuren S,van Eyk A,de Wet H

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Cotinus coggygria Scop. (Anacardiaceae) leaves that were used as wound healing in traditional Balkan and Anatolian folk medicine, could be potentially effective in treating diabetic wounds. OBJECTIVE:This study investigates biochemical and histological effects of ethanol extract of C. coggygria (CCE) on excisi...

journal_title：Pharmaceutical biology

authors： Aksoy H,Sen A,Sancar M,Sekerler T,Akakin D,Bitis L,Uras F,Kultur S,Izzettin FV

更新日期：2016-11-01 00:00:00

abstract：:Context 3,4-Oxo-isopropylidene-shikimic acid (ISA) is an analog of shikimic acid (SA). SA is extracted from the dry fruit of Illicium verum Hook. f. (Magnoliaceae), which has been used for treating stomachaches, skin inflammation and rheumatic pain. Objective To investigate the anti-inflammatory, analgesic and antioxi...

journal_title：Pharmaceutical biology

authors： Sun JY,You CY,Dong K,You HS,Xing JF

更新日期：2016-10-01 00:00:00

abstract：:Context Phillyrea latifolia L. (Oleaceae), commonly found in the Mediterranean region in Turkey, is used as medicinal teas for weight loss and hyperglycaemia in folk medicine. Objective The study investigated the possible effects of P. latifolia leaves aqueous extract's on weight loss and biochemical-histological chan...

journal_title：Pharmaceutical biology

authors： Yazici-Tutunis S,Gurel-Gurevin E,Ustunova S,Demirci-Tansel C,Mericli F

更新日期：2016-10-01 00:00:00

abstract：CONTEXT:Amaranthus spinosus Linn. (Amaranthaceae), commonly known as ''spiny pigweed'', is used in both Indian traditional system and folk medicine for treatment of infectious diseases for a long time in several traditional herbal medicinal preparations. A novel fatty acid [(14E, 18E, 22E, 26E)-methyl nonacosa-14, 18, ...

journal_title：Pharmaceutical biology

authors： Mondal A,Maity TK

更新日期：2016-10-01 00:00:00

abstract：:Context Acetaminophen (APAP), also known as paracetamol and N-acetyl p-aminophenol, is one of the most frequently used drugs for analgesic and antipyretic purposes on a worldwide basis. It is safe and effective at recommended doses but has the potential for causing hepatotoxicity and acute liver failure (ALF) with ove...

journal_title：Pharmaceutical biology

authors： Eugenio-Pérez D,Montes de Oca-Solano HA,Pedraza-Chaverri J

更新日期：2016-10-01 00:00:00

abstract：:Context Gelidiella acerosa (Forsskål) Feldmann & G. Hamel (Rhodophyta-Gelidiales) is a marine red macroalga. Our previous work found that a benzene extract of G. acerosa possesses noticeable neuroprotective activity, when evaluated through in vitro and in vivo systems. Objective Bioactive-guided fractionation and iden...

journal_title：Pharmaceutical biology

authors： Syad AN,Rajamohamed BS,Shunmugaiah KP,Kasi PD

更新日期：2016-10-01 00:00:00

abstract：:Context Diabetes is a global health challenge. Although large prospective clinical trials have shown that intensive control of blood glucose or blood pressure reduces the risk for development and progression of vascular complications in diabetes, a substantial number of diabetic patients still experience renal failure...

journal_title：Pharmaceutical biology

authors： Yamagishi S,Matsui T

更新日期：2016-10-01 00:00:00

abstract：:Context Shengmai injection (SMI) is a patented Chinese medicine originated from the ancient Chinese herbal compound Shengmai san, which is used extensively for the treatment of cardiovascular and cerebrovascular disease in the clinic. Objective To determine the neuroprotective effect of SMI, we investigated the effect...

journal_title：Pharmaceutical biology

authors： Yang H,Li L,Zhou K,Wang Y,Guan T,Chai C,Kou J,Yu B,Yan Y

更新日期：2016-10-01 00:00:00

abstract：:Context Ginseng is a widely used herbal medicine in China but its mechanism of action remains unclear. Objective The objectives of this work were to study the protective effect of ginsenoside Rg1 on subacute murine renal damage induced by d-galactose and its mechanism. Materials and methods C57BL/6J mice were injected...

journal_title：Pharmaceutical biology

authors： Fan Y,Xia J,Jia D,Zhang M,Zhang Y,Huang G,Wang Y

更新日期：2016-09-01 00:00:00

abstract：:Context Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally used by local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes, however, no definitive experimental studies are available. Objective This study investigates the antidiabetic, antihyperlipidaemic and antioxidant...

journal_title：Pharmaceutical biology

authors： Krishnasamy G,Muthusamy K,Chellappan DR,Subbiah N

更新日期：2016-09-01 00:00:00

abstract：:Context Pelargonium sidoides DC (Geraniaceae) is an important medicinal plant indigenous to South Africa and Lesotho. Previous studies have shown that root extracts are rich in polyphenolic compounds with antibacterial, antiviral and immunomodulatory activities. Little is known regarding the anticancer properties of P...

journal_title：Pharmaceutical biology

authors： Pereira A,Bester M,Soundy P,Apostolides Z

更新日期：2016-09-01 00:00:00

abstract：:Context Worldwide ethnobotanical research has shown the importance of home gardens as sources of medicinal plants. These resources are worthy of further study in the Argentinean Atlantic Forest due to the richness of medicinal flora and their importance for local people. Objective We studied richness, composition, cul...

journal_title：Pharmaceutical biology

authors： Furlan V,Kujawska M,Hilgert NI,Pochettino ML

更新日期：2016-09-01 00:00:00

abstract：:Context Phyllanthus emblica L. (Euphorbiaceae) (amla), Manilkara zapota L.P. Royen (Sapotaceae) (sapota) and silymarin are reported to contain antioxidant effects. However, information on other biological activities relating to the anti-aging properties is limited. Objective To compare in vitro antioxidants, anti-coll...

journal_title：Pharmaceutical biology

authors： Pientaweeratch S,Panapisal V,Tansirikongkol A

更新日期：2016-09-01 00:00:00

abstract：:Context The bark of Ailanthus altissima (Mill.) Swingle (Simaroubaceae) is traditionally used to treat ascariasis, diarrhoea, spermatorrhoea, bleeding and gastrointestinal diseases. Objective The objective of this study is to investigate the antitumour activity and mechanism of 2-dihydroailanthone isolated from A. alt...

journal_title：Pharmaceutical biology

authors： Wang R,Xu Q,Liu L,Liang X,Cheng L,Zhang M,Shi Q

更新日期：2016-09-01 00:00:00

abstract：:Context Yellow tea containing the same catechins as other types of tea but in different proportions has been suggested to possess potent anticancer activities. Objective This study investigates the chemopreventive effect of yellow tea aqueous extract against N-nitrosodiethylamine (NDEA)-induced liver carcinogenesis in...

journal_title：Pharmaceutical biology

authors： Kujawska M,Ewertowska M,Adamska T,Ignatowicz E,Gramza-Michałowska A,Jodynis-Liebert J

更新日期：2016-09-01 00:00:00

abstract：:Context Previous studies have shown that Scutellariae Radix, the dried root of Scutellaria baicalensis Georgi (Labiatae), has a certain inhibitory effect on P-glycoprotein (P-gp), but the effects of its main active constituents on P-gp are still ambiguous. Objectives In vitro studies were performed to investigate the ...

journal_title：Pharmaceutical biology

authors： Miao Q,Wang Z,Zhang Y,Miao P,Zhao Y,Zhang Y,Ma S

更新日期：2016-09-01 00:00:00

abstract：:Context The underground edible tuber of Dioscorea alata L. (Dioscoreaceae) is a functional food with high nutritive value and therapeutic potential. The tuber is known to possess anti-inflammatory properties in traditional medicine. Objective The present study explores the anti-inflammatory activity and standardisatio...

journal_title：Pharmaceutical biology

authors： Dey P,Roy Chowdhuri S,Sarkar MP,Chaudhuri TK

更新日期：2016-08-01 00:00:00